Effect of amiodarone on serum triiodothyronine, reverse triiodothyronine. changes thyroid hormone metabolism, possibly by reducing deiodination of T4 to T3. antibiotico augmentin per otite Thyroiditis, drug-induced thyroid disorders (amiodarone, interferon gamma). by decreasing peripheral deiodination of thyroxine (T4) to tri-iodothyronine (T3). 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